An online registry has been available since October 28, 2022 for healthcare providers and their affiliated medical facilities providing TPOXX under the CDC-held expanded access Investigational New Drug (IND) protocol to register as participating providers and sites. The online registry is to:

  • Assist providers and facilities providing TPOXX under the EA-IND protocol to be in compliance with U.S. Food and Drug Administration (FDA) IND regulations.
  • Allow providers' access to electronic TPOXX IND forms for completing and returning to CDC in more convenient, time-efficient, and secure manner.

Please be informed that system-generated emails containing tokenized links to electronic TPOXX IND forms (Patient Intake Form and Clinical Outcome Form) are sent to individual providers' email addresses. Therefore, providers must provide valid business emails to receive the tokenized links to these electronic forms. This public-facing online registry, which requires providers to enter their email addresses, bridges the providers' access to secure the electronic TPOXX IND forms.

For questions on TPOXX IND registry or electronic forms, please email

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